Prof. Kee-jung YOON Research Team of SKKU Integrative Biotechnology department, Identification of mechanism by which can
- 생명공학대학
- Hit2094
- 2018-12-13
Prof. Kee-jung YOON Research Team of SKKU
Integrative Biotechnology department, Identification of mechanism by which
cancer-related genes regulate normal neural stem cell activity and brain
morphogenesis
- Open the way to understand brain
formation process through regulation of neural stem cells –
Prof. Kee-jung YOON Research Team of SKKU
Integrative Biotechnology department has found that the Ttyh1 gene, known to be
expressed at high levels in cancer cells, is necessary for maintaining the
stemness of neural stem cells.
The researchers found that Ttyh1 protein
induces an increase in the activity of gamma secretase enzymes, strengthens the
Notch signaling pathway, and thereby enhances the self-proliferation of neural
stem cells important for brain formation.
Professor Kee-jung Yoon, who led the study,
said, "Cancer cells and normal stem cells share many cell signaling
systems. The significance of this study is that Ttyh1, which is suspected of
causing cancer, is an important gene related to normal brain formation."
The results of this study were published on
November 1st in the EMBO reports (Impact Factor: 8.74), a global authority on
molecular biology.
The research was conducted with support
project for middle-grade researchers promoted by the Ministry of Science and
ICT and the Korea Research Foundation. Professor Kee-Jung YOON is a
corresponding author and Dr. Ju-wan KIM (Department of Integrative
Biotechnology) is the lead author.