지방세포의 에너지 대사 촉진을 통한 비만 치료 기술 연구
천연물의 비만 및 대사질환에 대한 유효성 평가 및 기전연구
분자적 기전 연구를 통한 신규 표적 발굴 연구
학력
2004년 University of Utah 박사학위 취득
약력/경력
UCLA 병리학연구실 박사후연구원(2005 - 2009)
유타대 분자생물학 과정 연구원 (2004 -2005)
학술지 논문
(2025)
Phenethyl Isothiocyanate (PEITC) interaction with Keap1 activates the Nrf2 pathway and inhibits lipid accumulation in adipocytes..
JOURNAL OF NUTRITIONAL BIOCHEMISTRY.
144,
109963
(2024)
Butein derivatives prevent obesity and improve insulin resistance through the induction of energy expenditure in high-fat diet-fed obese mice.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES.
199,
106820
(2024)
Sesamolin suppresses adipocyte differentiation through Keap1-dependent Nrf2 activation in adipocytes..
NUTRITION RESEARCH.
128,
1
(2022)
Butein Ameliorates Oxidative Stress in H9c2 Cardiomyoblasts through Activation of the NRF2 Signaling Pathway.
ANTIOXIDANTS.
11,
8
(2021)
Butein-Enriched Fractions of Butea monosperma (Lam.) Taub. Flower Decrease Weight Gains and Increase Energy Expenditure in High-Fat Diet-Induced Obese Mice.
JOURNAL OF MEDICINAL FOOD.
24,
12
(2021)
A Role of Stress Sensor Nrf2 in Stimulating Thermogenesis and Energy Expenditure.
BIOMEDICINES.
9,
9
(2021)
Nrf2 induces Ucp1 expression in adipocytes in response to beta 3-AR stimulation and enhances oxygen consumption in high-fat diet-fed obese mice.
BMB REPORTS.
54,
8
(2020)
Sesamol Increases Ucp1 Expression in White Adipose Tissues and Stimulates Energy Expenditure in High-Fat Diet-Fed Obese Mice.
NUTRIENTS.
12,
5
(2019)
Identification of Phf16 and Pnpla3 as new adipogenic factors regulated by phytochemicals.
JOURNAL OF CELLULAR BIOCHEMISTRY.
120,
3
(2019)
Oxyresveratrol Increases Energy Expenditure through Foxo3a-Mediated Ucp1 Induction in High-Fat-Diet-Induced Obese Mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.
20(1),
26
(2019)
Sulfuretin Prevents Obesity and Metabolic Diseases in Diet Induced Obese Mice.
BIOMOLECULES & THERAPEUTICS.
27,
1
(2018)
Atf3 induction is a therapeutic target for obesity and metabolic diseases.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.
504,
4
(2018)
PI3Ka-Akt1-mediated Prdm4 induction in adipose tissue increases energy expenditure, inhibits weight gain, and improves insulin resistance in diet-induced obese mice.
CELL DEATH & DISEASE.
9,
9
(2017)
Induction of thermogenic adipocytes: molecular targets and thermogenic small molecules.
EXPERIMENTAL AND MOLECULAR MEDICINE.
49,
(2016)
Small Molecule-Induced Complement Factor D (Adipsin) Promotes Lipid Accumulation and Adipocyte Differentiation.
PLOS ONE.
11,
9
(2016)
Prdm4 induction by the small molecule butein promotes white adipose tissue browning.
NATURE CHEMICAL BIOLOGY.
12,
7
(2016)
B cell translocation gene 2 (Btg2) is regulated by Stat3 signaling and inhibits adipocyte differentiation.
MOLECULAR AND CELLULAR BIOCHEMISTRY.
413,
1-2
(2016)
Notch1 deficiency decreases hepatic lipid accumulation by induction of fatty acid oxidation.
SCIENTIFIC REPORTS.
6,
19377
(2016)
Antiadipogenic and proosteogenic effects of luteolin, a major dietary flavone, are mediated by the induction of DnaJ (Hsp40) Homolog, Subfamily B, Member 1.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY.
30,
1
특허/프로그램
COMPOSITION FOR INDUCING DIFFERENTIATION INTO BEIGE AND BROWN ADIPOCYTES AND METHOD OF INDUCING THE SAME.
14/745.772.
20170124.
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