HOME > 교수소개 >유전공학과

유전공학과

교수_유전공학 게시글의 상세 화면
성명
이종성  이메일
직위
연구실
생명공학관 62152호
전공 및 연구분야
세포생물학 및 피부과학
전화번호
031-290-7861
학력
홈페이지
https://skkumoldermatol.wixsite.com/bioneer-1


 학력

서울대학교 제약학과 박사학위 취득




 연구실적

1. Lee J, Oh SW, Shin SW, Lee KW, Cho JY, Lee J. Zingerone protects keratinocyte stem cells from UVB-induced damage. Chem Biol Interact. 2018 Jan 5;279:27-33.

2. Lee DY*, Lee J*, Jeong YT, Byun GH, Kim JH. Melanogenesis inhibition activity of floralginsenoside A from Panax ginseng berry. J. Ginseng Res. 2017 Oct;41(4):602-607. (*Co-first author)

3. Park SH, Kang M, Oh S, Kim Y, Kulkarni A, Moh SH, Lee J. Approaches for Development of Anti-Obesity Agents Using Natural Compounds and Microbiota Modification. Sci Adv Mater. 2017 Aug;9(8):1285-1295.

4. Hwang YS, Kim YJ, Kim MO, Kang M, Oh SW, Nho YH, Park SH, Lee J. Cannabidiol upregulates melanogenesis through CB1 dependent pathway by activating p38 MAPK and p42/44 MAPK. Chem Biol Interact. 2017 Aug;273: 107-114.

5. Hwang YS, Park SH, Kang M, Oh SW, Jung K, Park YS, Lee J. Stemness and differentiation potential-recovery effects of sinapic acid against ultraviolet-A-induced damage through the regulation of p38 MAPK and NF-κB. Sci Rep. 2017 Apr 19;7(1):909.

6. Kim MH*, Lee J*, Jung S, Kim JW, Shin JH, Lee HJ. The involvement of ginseng berry extract in blood flow via regulation of blood coagulation in rats fed a high-fat diet. J Ginseng Res. 2017 Apr;41(2):120-126. (*Co-first author)

7. Park SJ, Kim MO, Kim JH, Jeong S, Kim MH, Yang SJ, Lee J, Lee HJ. Antioxidant Activities of Functional Beverage Concentrates Containing Herbal Medicine Extracts. Prev Nutr Food Sci. 2017 Mar;22(1):16-20.

8. Park S*, Lee J*, Lee SY. IDH-Inhibiting Small Molecule DTDQ Inhibits Migration and Invasion of A549 Human Non-Small-Cell Lung Cancer Cells via Sequential Inactivation Of ERK and P38 Signaling Pathways. Cell Biochem Biophys. 2017 Mar 21. doi: 10.1007/s12013-017-0789-2. (*Co-first author)

9. Lee J, Nho YH, Yun SK, Hwang YS. Use of ethanol extracts of Terminalia chebula to prevent periodontal disease induced by dental plaque bacteria. BMC Complement Altern Med. 2017 Feb 16;17(1):113.

10. Park SH*, Phuc NM*, Lee J*, Wu Z, Kim J, Kim H, Kim ND, Lee T, Song KS, Liu KH. Identification of acetylshikonin as the novel CYP2J2 inhibitor with anti-cancer activity in HepG2 cells. Phytomedicine. 2017 Jan 15;24:134-140. (*Co-first author)

11. Jung E, Kim JH, Kim MO, Lee SY, Lee J. Melanocyte-protective effect of afzelin is mediated by the Nrf2-ARE signalling pathway via GSK-3β inactivation. Exp Dermatol. 2016 Dec 19;26(9):764-770.

12. Cho KW, Lee J, Kim Y. Genetic Variations Leading to Familial Dilated Cardiomyopathy. Mol Cells. 2016 Oct;39(10):722-727. Review.

13. Lee J, Shin MS, Kim MO, Jang S, Oh SW, Kang M, Jung K, Park YS, Lee J. Apple ethanol extract promotes proliferation of human adult stem cells, which involves the regenerative potential of stem cells. Nutr Res. 2016 Sep;36(9):925-936.

14. Park SH*, Lee J*, Kang MA, Moon YJ, Wang SI, Kim KM, Park BH, Jang KY, Kim JR. Potential of l-thyroxine to differentiate osteoblast-like cells via Angiopoietin1. Biochem Biophys Res Commun. 2016 Sep 23;478(3):1409-1415. (*Co-first author)

15. Roh KB, Kim H, Shin S, Kim YS, Lee JA, Kim MO, Jung E*, Lee J*, Park D. Anti-inflammatory effects of Zea mays L. husk extracts. BMC Complement Altern Med. 2016 Aug 19;16(1):298. (*Co-corresponding author)

16. Lee SY, Park SH, Kim MO, Lim I, Kang M, Oh SW, Jung K, Jo DG, Cho IH, Lee J. Vanillin attenuates negative effects of ultraviolet A on the stemness of human adipose tissue-derived mesenchymal stem cells. Food Chem Toxicol. 2016 Oct;96:62-69.

17. Jung O*, Lee J*, Lee YJ, Yun JM, Son YJ, Cho JY, Ryou C, Lee SY. Timosaponin AIII inhibits migration and invasion of A549 human non-small-cell lung cancer cells via attenuations of MMP-2 and MMP-9 by inhibitions of ERK1/2, Src/FAK and β-catenin signaling pathways. Bioorg Med Chem Lett. 2016 Aug 15;26(16):3963-3967. (*Co-first author)

18. Lee J, Park SH. Tumor-suppressive activity of 1,25-dihydroxyvitamin D3 against kidney cancer cells via up-regulation of FOXO3. May. 16, 2016, Biosci Biotechnol Biochem.

19. Jung E, Kim JH, Kim MO, Jang S, Kang M, Oh SW, Nho YH, Kang SH, Kim MH, Park SH*, Lee J*. Afzelin positively regulates melanogenesis through the p38 MAPK pathway. Jul. 25, 2016, Chemico-Biological Interactions. 254: 167-172 (*Co-corresponding author)

20. Yu T*, Rhee MH*, Lee J*, Kim SH, Yang Y, Kim HG, Kim Y, Kim C, Kwak YS, Kim JH, Cho JY. Ginsenoside Rc from Korean Red Ginseng (Panax ginseng C.A. Meyer) Attenuates Inflammatory Symptoms of Gastritis, Hepatitis and Arthritis. Apr. 24, 2016, Am J Chin Med. 44(3): 595-615 (*Co-first author)

21. Choi HR, Nam KM, Lee HS, Yang SH, Kim YS, Lee J, Date A, Toyama K, Park KC. Phlorizin, an Active Ingredient of Eleutherococcus senticosus, Increases Proliferative Potential of Keratinocytes with Inhibition of MiR135b and Increased Expression of Type IV Collagen. Mar. 06, 2016, Oxid Med Cell Longev. 2016: 3859721.

22. Kim MO, Park YS, Nho YH, Yun SK, Kim Y, Jung E, Paik JK, Kim M, Cho IH*, Lee J*. Emodin isolated from Polygoni Multiflori Ramulus inhibits melanogenesis through the liver X receptor-mediated pathway. Apr. 25, 2016, Chemico-Biological Interactions. 250: 78-84 (*Co-corresponding author)

23. Hwang YS*, Lee J*, Zhang X, Lindholm PF. Lysophosphatidic acid activates the RhoA and NF-κB through Akt/IκBα signaling and promotes prostate cancer invasion and progression by enhancing functional invadopodia formation. May, 2016, Tumor Biology. 37(5): 6775-6785 (*Co-first author)

24. Kim M, Shin S, Lee JA, Park D, Lee J*, Jung E*. Inhibition of melanogenesis by Gaillardia aristata flower extract. Dec. 24, 2015, BMC Complement Altern Med. 15: 449 (*Co-corresponding author)

25. Shin S, Son D, Kim M, Lee S, Roh KB, Ryu D, Lee J*, Jung E*, Park D. Ameliorating Effect of Akebia quinata Fruit Extracts on Skin Aging Induced by Advanced Glycation End Products. Nov. 12, 2015, Nutrients. 7(11): 9337-9352 (*Co-corresponding author)

26. Ji Hyun Kim*, Eun Byul Cho*, Jongsung Lee*, Okkeun Jung, Byung Jun Ryu, Seong Hwan Kim, Jae Youl Cho, Chongsuk Ryou, Sang Yeol Lee. Emetine inhibits migration and invasion of human non-small-cell lung cancer cells via regulation of ERK and p38 signaling pathways. Dec. 05, 2015, Chemico-Biological Interactions. 242: 25-33 (*Co-first author)

27. Kwangseon Jung*, Jae Youl Cho*, Young-Jin Soh*, Jienny Lee, Seoung Woo Shin, Sunghee Jang, Eunsun Jung, Min Hee Kim, Jongsung Lee. Antagonizing effects of aspartic acid against Ultraviolet A-induced downregulation of the stemness of human adipose tissue-derived mesenchymal stem cells. Apr. 2015, PLOS One. 10(4): e0124417. (*Co-first author)

28. Shi Hyoung Kim*, Jae Gwang Park*, Jongsung Lee*, Woo Seok Yang, GyeWon Park, Han Gyung Kim, Young-Su Yi, Kwang-Soo Baek, Nak Yoon Sung, Muhammad Jahangir Hossen, Mi-nam Lee, Jong-Hoon Kim, Jae Youl Cho1. The Dietary Flavonoid Kaempferol Mediates Anti-Inflammatory Responses via the Src, Syk, IRAK1, and IRAK4 Molecular Targets. Apr. 2015, Mediators of Inflammation. 2015: Article ID 904142 (*Co-first author)

29. Min Jung Ku*, Ji Hyun Kim*, Jongsung Lee*, Jae Youl Cho, Taehoon Chun, Sang Yeol Lee. Maclurin suppresses migration and invasion of human non-small-cell lung cancer cells via anti-oxidative activity and inhibition of the Src/FAK-ERK-β-catenin pathway. Apr. 2015, Molecular and Cellular Biochemistry. 402: 243-252 (*Co-first author)

30. To Thi Mai Dung*, Jongsung Lee*, Eunji Kim*, Byong Chul Yoo, Ha Van Thai, Yong Kim, Deok Hyo Yoon, Kwang-Soo Baek, Nak Yoon Sung, Tae Woong Kim, Sungyoul Hong, J Kim, Jae Youl Cho. Anti-inflammatory activities of Gouania leptostachya methanol extract and its constituent resveratrol. Mar. 2015, Phytotherapy Research. 29: 381-392

31. Eunsun Jung, Jae Youl Cho, Deokhoon Park, Min Hee Kim, Beomseok Park, Sang Yeol Lee*, Jongsung Lee*. Vegetable peptones increase production of type I collagen in human fibroblasts by inducing the RSK-CCAAT/enhancer binding protein-β phosphorylation pathway. Feb. 2015, Nutrition Research. 35(2): 127-135.  

32. Yanyan Yang*, Jongsung Lee*, Man Hee Rhee*, Tao Yu, Kwang-Soo Baek, Nak Yoon Sung, Yong Kim, Keejung Yoon, Ji Hye Kim, Yi-Seong Kwak, Sungyoul Hong, Jong-Hoon Kim, Jae Youl Cho. Molecular mechanism of protopanaxadiol saponin fraction-mediated anti-inflammatory actions. Jan. 2015, Journal of Ginseng Research. 39(1): 61-68 (*Co-first author).

33. Byung Jun Ryu, Hyuk Lee, Seong-Ho Kim, Jung-Nyoung Heo, Sik-Won Choi, Jeong-Tae Yeon, Jeongmin Lee, Jongsung Lee, Jae Youl Cho, Seong Hwan Kim, Sang Yeol Lee. PF-3758309, p21-activated kinase 4 inhibitor, suppresses migration and invasion of A549 human lung cancer cells via regulation of CREB, NF-κB, and β-catenin signalings. Apr. 2014, Molecular and Cellular Biochemistry. 389(1-2): 69-77

34. Sang Yeol Lee, Young-Jin So, Moon Sam Shin, Jae Youl Cho*, Jongsung Lee*. Antibacterial effects of afzelin isolated from Cornus macrophylla on Pseudomonas aeruginosa, a leading cause of illness in immunocompromised individuals. Mar. 2014, Molecules. 19(3): 3173-3180 (Corresponding author)

35. Jienny Lee, Jae Youl Cho, Sang-Yeol Lee, Kyung-Woo Lee*, Jongsung Lee*, Jae-Young Song. Vanillin Protects Human Keratinocyte Stem Cells against Ultraviolet B Irradiation. Jan. 2014, Food Chemical Toxicology. 63: 30-37 (Corresponding author)

36. Sang-Eun Lee, Tae-Min Jo, Hyang-Yeol Lee, Jongsung Lee, Kyung-Hwan Jung. β-Galactosidase-catalyzed synthesis of galactosyl chlorphenesin and its characterization. Applied Biochemistry and Biotechnology. Nov. 2013, 171(6): 1299-1312.

37. Sang-Cheol Kim, Jin-Hyunk Lee, Moo-Han Kim, Jung-A Lee, Yum Beom Kim, Eunsun Jung, Young-Soo Kim, Jongsung Lee*, Deokhoon Park*. Hordenine, a single compound produced during barley germination, inhibits melanogenesis in human melanocytes. Nov. 1, 2013, Food Chemistry. 141(1): 174-181. (*Corresponding author)

38. Jienny Lee, Eunsun Jung, Young-Soo Kim, Deokhoon Park, Kazumi Toyama, Akira Date, Jongsung Lee. Phloridzin isolated from Acanthopanax senticosus promotes proliferation of α6 integrin (CD 49f) and β1 integrin (CD29) enriched for a primary keratinocyte population through the ERK-mediated mTOR pathway. Oct. 2013, Archives of Dermatological Research. 305 (8): 747-754.

39. Jueun Oh, Ho Sik Rho, Yanyan Yang, Ju Young Yoon, Jongsung Lee, Yong Deog Hong, Haryoung Poo, Sun Shim Choi, Tae Woong Kim, Song Seok Shin and Jae Youl Cho Extracellular signal-regulated kinase is a direct target of the anti-inflammatory compound amentoflavone, derived from Torreya nuncifera. July. 2013, Mediators of Inflammation. 2013: Article ID 761506, 11 pages.

40. Kyung-Baeg Roh, Eunsun Jung, Deokhoon Park*, Jongsung Lee*, Fumaric acid Attenuates the Eotaxin-1 Expression in TNF-a-Stimulated Fibroblasts by Suppressing p38 MAPK-dependent NF-κB Signaling. Aug. 2013, Food and Chemical Toxicology. 58: 423-431. (*Corresponding author).

41. Seoung Woo Shin, Eunsun Jung, Seungbeom Kim, Jang-Hyun Kim, Eui-Gyun Kim, Jongsung Lee*, Deokhoon Park*. Antagonizing effects and mechanisms of afzelin against UVB-induced cell damages. Apr. 2013, PLoS One. 8(4): e61971. doi:10.1371/journal.pone.0061971. (*Corresponding author)

42. Yongwoo Jung, Young-Su Yi, Dae Sung Yoo, Ji Hye Kim, Woo Seok Yang, Jongsung Lee, Gye Won Park, Dae Hyuk Kweon, Sungyoul Hong, Jae Youl Cho. 8-(tosylamino)quinoline inhibits tumour progression through targeting phosphoinositide-3-kinase/Akt pathway. Pharmazie. Feb. 2013, 68(2): 146-152.

43. Yanyan Yang, Gang Jun Lee, Deok Hyo Yoon, Tao Yu, Jueun Oh, Deok Jeong, Jongsung Lee, Seong Hwan Kim, Tae Woong Kim, Jae Y Cho. ERK1- and TBK1-targeted anti-inflammatory activity of an ethanol extract of Dryopteris crassirhizoma. Journal of Ethnopharmacology. Jan. 2013, 145(2): 499-508.

44. Jongsung Lee, Jienny Lee, Eunsun Jung, Jae Youl Cho, Deokhoon Park. Artemisinic acid inhibits melanogenesis through downregulation of C/EBP α-dependent expression of HMG-CoA reductase gene. Food and Chemical Toxicology. Jan. 2013, 51(1): 225-230.

45. Jongsung Lee, Eunsun Jung, Jinwon Hyun, Deokhoon Park. Ultraviolet A regulates the stemness of human adipose tissue-derived mesenchymal stem cells through downregulation of HIF-1 a via activation of PGE2-cAMP signaling. Journal of Cellular Biochemistry. Dec. 2012, 113(12): 3681-3691.

46. Kyung-Baeg Roh, Jienny Lee, Young-Soo Kim, Junho Park, Jang-Hyun Kim, Jongsung Lee*, Deokhoon Park*. Mechanisms of edible bird’s nest extract-induced proliferation of human adipose-derived stem cells. Evidence-Based Complementary and Alternative Medicine. Nov. 2012, 2012: 797520 (*Co-corresponding author)

47. Young-Soo Kim, Hyungil Kim, Eunsun Jung, Jang-Hyun Kim, Wangtaek Hwang, Eun-Ju Kang, Sanghyun Lee, Byung-Jo Ha, Jongsung Lee, Deokhoon Park. A novel antibacterial compound from Siegesbeckia glabrescens. Molecules. Oct. 2012, 17(11): 12469-12477

48. Jienny Lee, Kyungbaeg Roh, Sang-Cheol Kim, Jongsung Lee*, Deokhoon Park*. Soy peptide-induced stem cell proliferation: involvement of ERK and TGF-β1. Journal of Nutritional Biochemistry. Oct. 2012, 23(10): 1341-1351. (*Co-corresponding author)

49. Eunsun Jung, Sangyo Byun, Seungbeom Kim, Moohan Kim, Deokhoon Park*, Jongsung Lee*. Isomenthone protects human dermal fibroblasts from TNF-a-induced death possibly by preventing activation of JNK and p38 MAPK. Food and Chemical Toxicology. Oct. 2012, 50(10): 3514-3520. (*Co-corresponding author)

50. Jongsung Lee, Moo-Han Kim, Jin-Hyuck Lee, Eunsun Jung, Eun-Sook Yoo, Deokhoon Park. Artemisinic acid is a regulator of adipocyte differentiation and C/EBP δ expression. Journal of Cellular Biochemistry. July. 2012, 113(7): 2488~2499.

51. Seungbeom Kim, Eunsun Jung, Seungwoo Shin, Moohan Kim, Young-Soo Kim, Jongsung Lee*, Deokhoon Park*. Anti-inflammatory activity of Camellia japonica oil. BMB reports. March. 2012, 45(3): 177~182 (*Co-corresponding author)

52. Ki Cheon Kim, Sam Sik Kang, Jongsung Lee, Deokhoon Park, Jin Won Hyun. Baicalein attenuates oxidative stress-induced expression of Matrix Metalloproteinase-1 by regulating the ERK/JNK/AP-1 pathway in human keratinocytes. Biomolecules & Therapeutics. Jan. 2012, 20(1): 57~61.

53. Wang-Taek Hwang, Young-Soo Kim, Chan-Ki Hong, Jongsung Lee*, Doekhoon Park*. Simple stability-indicating validated HPLC method for diosgenin in cosmeceutical formulations. International Journal of Pharmacy and Pharmaceutical Sciences. Dec 2011, 3(suppl 5); 466-471 (*Co-corresponding author)

54. Eunsun Jung, Wangtaek Hwang, Young-Soo Kim, Seungbeom Kim, Yeong-Shik Kim, Jongsung Lee*, Deokhoon Park*. Depigmentation by platycodin D is mediated by cAMP-PKA/Rho-dependent signaling pathway. Experimental Dermatology. Dec. 2011, 20(12): 986-991 (*Co-corresponding author)

55. Seungbeom Kim, Eunsun Jung, Jang-Hyun Kim, Young-Ho Park, Jongsung Lee*, Deokhoon Park*. Inhibitory effects of (-)-α-bisabolol on LPS-induced inflammatory response in RAW264.7 macrophages. Food & Chemical Toxicology. Oct. 2011, 49(10): 2580-2585 (*Co-corresponding author)

56. Kyoung-ah Kang, Zhi-hong Wang, Rui Zhang, Mei-jing Piao, Ju-sun Kim, Sam-sik Kang, Yong-Woo Kim, Jongsung Lee, Deokhoon Park, Jin Won Hyun. Myricetin protects cells against oxidative stress-induced apoptosis via regulation of PI3K/Akt and MAPK signaling pathways. International Journal of Molecular Sciences. Nov. 2010, 11(11): 4348-4360.

57. Jongsung Lee, Jienny Lee, Eunsun Jung, Young-Soo Kim, Kyung-Hwan Jung, Deokhoon Park. Ultraviolet A regulates adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells via upregulation of Kruppel-like factor 2. Journal of Biological Chemistry. Oct.15 2010, 285(42): 32647-32656.

58. Jienny Lee, Jongsung Lee, Kyungbaeg Roh, Deokhoon Park. Melanocyte-Precursor Cell Induction from Human Cord Blood-Derived Mesenchymal Stem Cells. African Journal of Biotechnology. Sept. 2010, 9(36): 5975-5977.

59. Sungran Huh, Eunsun Jung, Jienny Lee, Kyung Baek Noh, Ju-Duck Kim, Jongsung Lee*, Deokhoon Park*. Mechanisms of depigmentation by propafenone. Archives of Dermatological Research. Sept. 2010, 302(7): 561-565. (*Co-corresponding author).

60. Jongsung Lee, Hyunjung Jun, Eunsun. Jung, Jaehyoun Ha, Deokhoon Park. Whitening effect of a-bisabolol in Asian women. International Journal of Cosmetic Science. Aug 2010, Aug. 32(4) 299-303 (Faculty of 1000).

61. Sungran Huh, Young-Soo Kim, Eunsun Jung, Jihee Lim, Kwang Sun Jung, Myeong-Ok Kim, Jongsung Lee, Deokhoon Park. Melanogenesis inhibitory effect of fatty acid alkyl esters isolated from Oxalis triangularis. Biological & Pharmaceutical Bulletin. July 2010, 33(7): 1242-1245.

62. In Jin Ha, Young Wan Ha, Minseok Kang, Jongsung Lee, Deokhoon Park, Yeong Shik Kim. Enzymatic transformation of platycosides and one step separation of platycodin D by high-speed counter-current chromatography. Journal of Separation Science. Jun 2010, 33(13): 1916-1922.

63. Jongsung Lee, Jienny Lee, Eunsun Jung, Wangtaek Hwang, Yeong-Shik Kim, Deokhoon Park. Isorhamnetin-induced antiadipogenesis is mediated by stabilization of β-catenin protein. Life Sciences. March 2010, 86(11-12): 416-423.

64. Jongsung Lee, Eunsun Jung, Jienny Lee, Sungran Huh, Young-Soo Kim, Yeong-Shik Kim, Deokhoon Park. Anti-adipogenesis by 6-thioinosine is mediated by downregulation of PPAR γ through JNK-dependent upregulation of iNOS. Cellular and Molecular Life Sciences. Feb 2010, 67(3): 467-481.

65. Young-Soo Kim, Ji-Young Lee, Junho Park, Wangtek Hwang, Jongsung Lee, Deokhoon Park. Synthesis and microbiological evaluation of honokiol derivatives as new antibacterial agents. Archives of Pharmacal Research. Jan 2010, 33(1): 61-65.

66. Zhi-hong Wang, Kyoung-ah Kang, Rui Zhang, Mei-jing Piao, Su-hyun Jo,Ju-sun Kim, Sam-sik Kang, Jongsung Lee, Deokhoon Park, Jin-won Hyun. Myricetin suppresses oxidative stress-induced cell damage via both direct and indirect antioxidant. Environmental Toxicology and Pharmacology. Jan 2010, 29(1): 12-18.

67. Eunsun Jung*, Jongsung Lee*, #, Sungran Huh, Jienny Lee, Young-Soo Kim, Kyedong Kim, Deokhoon Park#. Phloridzin-induced melanogenesis is mediated by cAMP signaling pathway. Food & Chemical Toxicology. Oct 2009, 47(10): 2436-2440 (*: co-first, #:co-corresponding author).

68. Jienny Lee, Jongsung Lee, Hyunjin Hwang, Eunsun Jung, Sungrah Huh, Deokhoon Park. Promotion of stem cell proliferation by vegetable peptone. Cell proliferation. Oct 2009, 42(5): 595-601.

69. Sungran Huh*, Jongsung Lee*, Eunsun Jung, Sang-Cheol Kim, Jienny Lee, Young Kwan Sung, Hee-Kyoung Kang, Deokhoon Park. A cell-based system for screening hair growth-promoting agents. Archives of Dermatological Research. Jun 2009, 301(5): 381-385 (*: co-first author).

70. Saebom Kim*, Jongsung Lee*, Eunsun Jung, Sungran Huh, Jienny Lee, Hyeonjin Hwang, Deokhoon Park. 6-benzylaminopurine (6-BAP) stimulates the melanogenesis by cAMP independent activation of Protein kinase A (PKA). Archives of Dermatological Research. March 2009, 301(3): 253-258 (*:co-first author).

71. Jongsung Lee*, Eunsun Jung*, Jienny Lee, Saebom Kim, Sungran Huh, Youngsoo Kim, Yongwoo Kim, Sang Yo Byun, Yeong-Shik Kim, Deokhoon Park. Isorhamnetin represses adipogenesis in 3T3-L1 cells. Obesity. Feb 2009, 17(2): 226-232. (*: co-first author).

72. Jongsung Lee, Eunsun Jung, Heekung Lee, Youngkyung Seo, Jassook Koh, Deokhoon Park. Effect of a preparation containing asiaticoside on periocular wrinkles of human voluntaries. International Journal of Cosmetic Science. Mar. 2008, 30(3) 167-173.

73. Jongsung Lee, Eunsun Jung, Yeong-Shik Kim, Deokhoon Park. Effect of rosmarinic acid on patients with atopic dermatitis. Journal of Dermatology. Dec 2008, 35(12): 768–771.

74. Jongsung Lee, Eunsun Jung, Hyunkyung Yu, Yongwoo Kim, Jaehyoun Ha, Yeong Shik Kim, Deokhoon Park. Mechanisms of carvacrol-induced expression of type I collagen gene. Journal of Dermatological Science. Dec. 2008, 52(3), 160-169.

75. Saebom Kim*, Jongsung Lee*, Eunsun Jung*, Sungran Huh, Jin-Oh Park, Ji-won  Lee, Sang Yo Byun, Deokhoon Park. Mechanisms of depigmentation by α-bisabolol. Journal of Dermatological Science. Dec. 2008, 52(3), 219-222 (*: co-first author).

76. Jiyoung Lee, Jongsung Lee, Wonhyuck Yang, Jihee Lim, Sanghee Sim, Deokhoon Park. Antibacterial activities of Butyrolactone from Spiraea thunbergii Sieb. against foodborne pathogenic microorganisms. Journal of Medicinal Plants Research. Mar. 2008, 2(3), 59-65.

77. Eunsun Jung*, Jongsung Lee*, Sungran Huh, Jienny Lee, Deokhoon Park. Matrine inhibits PMA-induced MMP-1 expression in human dermal fibroblasts. Biofactors. 2008, 33(2): 121-128 (*:co-first author).

78. Jongsung Lee, Yeong-Shik Kim, Deokhoon Park. Rosmarinic acid induces melanogenesis through protein kinase A activation signaling. Biochemical Pharmacology. Oct 2007, 74(7), 960-968.

79. Jongsung Lee*, Eunsun Jung*, Sungran Huh, Jiyoung Lee, Yeong-Shik Kim, Deokhoon Park. Mechanisms of melanogenesis inhibition by DMHF. British Journal of Dermatology. Aug 2007, 157(2), 242-248 (*:co-first author).

80. Jongsung Lee, Kwangseon Jung, Yeong-Shik Kim, Deokhoon Park. Diosgenin inhibits melanogenesis through the activation of Phosphatidylinositol-3- kinase Pathway (PI3K) signaling. Life Sciences. Jun 2007, 81(3), 249-254.

81. Eunsun Jung*, Jongsung Lee*, Jihoon Baek, Kwangsun Jung, Jiyoung Lee, Sungran Huh, Jaesook Koh, Deokhoon Park. Effect of Camellia japonica oil on human type I procollagen production and skin barrier function. Journal of Ethnopharmacology. May 2007, 112, 127-131 (*:co-first author).

82. Sungran Huh*, Jongsung Lee*, Yeonggeun Ham, Sang Suk Kim, Chang Gu Hyun, Yeong Shik Kim, Deokhoon Park. A cell-based assay system for high-throughput screening of anti-wrinkle agents in human dermal fibroblast transfectant cells. Biotechnology and applied Biochemistry. May 2007, 47(1), 27-31 (*:co-first author).

83. Jongsung Lee, Eunsun Jung, Jiyoung Lee, Sungran Huh, Jieun Kim, Mijung Park, Jungwoon So, Younggeun Ham, Kwangseon Jung, Chang-Gu Hyun, Yeong Shik Kim, and Deokhoon Park,. Panax ginseng induces human Type I collagen synthesis through activation of Smad signaling. Journal of Ethnopharmacology. Jan 2007, 109, 29-34.

84. Jongsung Lee, Eunsun Jung, Jiyoung Lee, Sungran Huh, Cheng-Hwan Hwang, Hwa-Young Lee, Eun-Jung Kim, Ji-Min Cheon, Changgu Hyun, Yeong Shik Kim, Deokhoon Park. Emodin inhibits TNF a-induced MMP-1 expression through suppression of JNK and p42/44MAPK. Life Sciences. Nov 2006, 79, 2480-2485.

85. Jongsung Lee, Eunsun Jung, Jihee Lim, Jiyoung Lee, Sungran Hur, Sang Suk Kim, Changgu Hyun, Yeong Shik Kim, Deokhoon Park. Involvement of nuclear factor-κB in the inhibition of pro-inflammatory mediators by pinosylvin. Planta Medica. July 2006, 72(9), 801-806.

86. Jongsung Lee, Eunsun Jung, Youngji Kim, Jiyoung Lee,Junho Park, Seongtaek Hong, Chang-Gu Hyun, Deokhoon Park, Yeong Shik Kim. Rosmarinic acid (RA) as a downstream inhibitor of IKK β in TNF a–induced upregulation of CCL11 & CCR-3. British Journal of Pharmacology. April 10, 2006, 148, 366-375.

87. Jongsung Lee, Eunsun Jung, Youngji Kim, Junho Park, Jinil Park, Sungtaek Hong, Jieun Kim, Changgu Hyun, Yeong Shik Kim, Deokhoon Park. Asiaticoside induces Human Collagen I Synthesis through TGFβreceptor I kinase (TβRI kinase)-independent Smad signaling. Planta Medica. March 2006, 72(4), 324-328.

88. Jongsung Lee, Eunsun Jung, Junho Park, and Deokhoon Park. Transdermal delivery of interferon g (IFNg) mediated by penetratin, a cell-permeable peptide. Biotechnology and applied Biochemistry. Oct 2005, 42(2), 169-173.

89. Jongsung Lee, Eunsun Jung, Junho Park, Byunghwa Park, Kwangseon Jung, Eunkyung Park, Jieun Kim, Sungtaek Hong, Jinil Park, Sanghee Park, Sangyeop Lee and Deokhoon Park. Glycyrrhizin(GR) induces melanogenesis by elevating a cAMP level in B16 melanoma cells. Journal of Investigative Dermatology. Feb 2005, 124(2), 405- 411.

90. Jongsung Lee, Eunsun Jung, Junho Park, Kukhyun Kim, Byunghwa Park, Kwangseon Jung, Eunkyung Park, Jieun Kim, and Deokhoon Park. Anti-inflammatory effects of magnolol and honokiol are mediated through inhibition of downstream pathway of the MEKK-1 in NF-κB activation signaling. Planta Medica. Apr 2005, 71(4), 338-343.

91. Jongsung Lee, Byunghwa Park, Kwangseon Jung, Kukhyun Kim, Kyu Han Kim and Deokhoon Park. Evaluation of the anti-inflammatory and atopic dermatitis-mitigating effects of BSASM, a multicompound preparation. Journal of Ethnopharmacology. Jan 2005, 96(1-2), 211-219

92. Junho Park*, Jongsung Lee*, Eunsun Jung, Yumi Park, Kukhyun Kim, Byunghwa Park, Kwangseon Jung, Eunkyung Park, Jieun Kim, and Deokhoon Park. In vitro antibacterial and anti-inflammatory activities of Honokiol and Magnolol against Propionibacterium sp.. European Journal of Pharmacology. Aug. 2004, 496(1-3), 189-195 (*: co-first author).

93. Haeyoung Jeong, Miran Kim, Jongsung Lee, Si Houn Hahn, Seonyang Park, Ook Joon Yoo. A 5-Nucleotide insertion in the antithrombin gene causing a quantitative antithrombin deficiency. Thrombosis and Haemostasis. 1997, 77(1)212-213

 


 


 연구분야

피부생리 조절 및 신호전달

줄기세포(피부 및 지방유래) 분화 및 활성 조절 연구

피부 질환 발생 기전 및 소재연구

비만과 피부이상간의 상관관계 연구

외부인자에 의한 피부이상 및 관련 기전연구 




 연구실

분자 피부과학 연구실은 피부의 구조와 생리현상을 분자적인 수준에서 체계적으로 연구하는 실험실입니다. 피부는 외부환경으로부터 인체를 보호하는 물리적 방어수단으로서의 장벽기능(barrier function) 뿐만 아니라 다양한 생리현상을 통해 인체를 보호 및 조절하는 가장 큰 기관(Organ)으로 알려져 있습니다.본 연구실은 외부 자극에 의해 발생하는 다양한 피부이상현상 (피부암, 피부 자가면역질환, 노화, 피부염증 질환, 색소이상 등)의 발생 기전을 체계적으로 연구하고, 궁극적으로는 피부이상을 개선할 수 있는 소재를 개발하고자 합니다. 또한, 피부 및 피하조직 유래 줄기세포의 stemness와 분화능(differentiation potential)을 조절할 수 있는 연구를 수행함으로써, 전반적인 피부의 항상성(Homeostasis) 유지 및 개선을 위한 방안을 강구하는데 주력하고자 합니다.

연구실험실 : 생명공학관 62254
교내전화 : 031-290-7891

목록